4/6/2023 0 Comments Fatigue adrenal![]() ![]() ![]() In addition, cortisol – sometimes called the “stress hormone” – must respond appropriately to all stresses impinging upon the host. The feedback loop that controls circulating cortisol must walk a tightrope walk, balancing at varying levels during the 24-h diurnal cycle in order to adequately supply cells, tissues and organs and keep the body functioning optimally. There is also a midafternoon low sometime between 2:00 and 5:00 pm, with a duration of 15 min to 2 h. These optimal circulating levels vary in a diurnal pattern, with low being at approximately 4:30 am and high being 30–45 min after rising. Regulated by the hypothalamic-pituitary-adrenal (HPA) axis and cortisol carriers in the blood possessing different affinities for cortisol binding, the level of circulating cortisol in a healthy body remains between 15 and 24 mcg/dL, with the adrenals producing 20–25 mg of cortisol over a 24 h period. If levels climb and remain above optimal for a period of time, signs and symptoms of metabolic syndrome appear pathologically high, and Cushing syndrome manifests. If levels drop much below optimal, signs and symptoms of adrenal fatigue occur if they drop precipitously low, as in Addison's disease, it can be life-threatening. But in order to do so, circulating levels must be maintained in a fairly narrow range. Cortisol plays a crucial role in maintaining health.
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